Product Overview
Purified recombinant protein of Human nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon (NFKBIE), with N-terminal HIS tag, expressed in E.coli.
Description
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]
Form
25mM Tris, pH 8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl
