Recombinant Human NOTCH2 Protein, C-His-tagged
Product Description
Cat
IMP-4856
Official Symbol
NOTCH2
Product Overview
Recombinant human NOTCH2 (NP_001186930.1) (Met1-Gln530) was expressed with a polyhistidine tag at the C-terminus.
Description
NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of developmental processes by controlling cell fate decisions. Hajdu Cheney Syndrome (HCS) is a rare disease associated with mutations of NOTCH2 that lead to the translation of a truncated, presumably stable, NOTCH2 protein. NOTCH2 is down-regulated in colon cancer, and reduced expression is associated with a less differentiated, more aggressive phenotype, and reduced overall survival. NOTCH2 has also been shown to have pro-apoptotic and growth-suppressive effects in thyroid carcinoma, and carcinoid tumors. NOTCH2 acts as an oncogene that promotes bladder cancer growth and metastasis through EMT, cell-cycle progression, and maintenance of stemness.
Expression System
Insect cell
Species
Human
Tag
C-His
Predicted N Terminal
Leu 26
Form
Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 %gly, pH 8.0, 5 % trehalose, 5% mannitol and 0.01% Tween80.
Molecular Mass
The recombinant human NOTCH2 consists of 516 amino acids and predicts a molecular mass of 55.5 kDa.
Protein length
Met1-Gln530
Endotoxin
< 1.0 EU/μg of the protein as determined by the LAL method
Purity
> 95 % as determined by SDS-PAGE
Storage
Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
SDS-PAGE
SDS-PAGE

Data Sheet MSDS
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Online Inquiry
Contact Info