Recombinant Human PCSK9 Protein (Arg29-Gln692), C-His-tagged
Product Description
Cat
IMP-7762
Official Symbol
Pcsk9
Product Overview
Purified recombinant protein of Human proprotein convertase subtilisin/kexin type 9 (PCSK9) with a C-His tag was expressed in CHO.
Description
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Expression System
CHO
Species
Human
Tag
C-His
Form
25mM sodium Acetate, 150mM NaCl, pH5.0
Molecular Mass
73 kDa
Protein length
Arg29-Gln692
Endotoxin
< 1.0 EU/μg protein as determined by the LAL method
Purity
> 90% as determined by SDS-PAGE and Coomassie blue staining.
Storage
Store at -80 centigrade.
Stability: Unopened vial can be stored between 2 and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Concentration
lot specific
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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