Recombinant Human PCSK9 Protein, C-His-tagged, Biotinylated
Product Description
Cat
IMP-4871
Official Symbol
PCSK9
Product Overview
Recombinant human PCSK9 (NP_777596.2, natural mutation Val 474 Ile and Gly 670 Glu) (Met 1-Gln 692) was expressed with a C-terminal polyhistidine tag. The purified protein was biotinylated in vitro.
Description
Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
Expression System
HEK293
Species
Human
Tag
C-His
Predicted N Terminal
Gln 32
Form
Lyophilized from sterile Sterile PBS, 5 % trehalose, 5% mannitol and 0.01% Tween80.
Molecular Mass
The recombinant PCSK9 consists of 662 amino acids and predicts a molecular mass of 71.1 kDa.
Protein length
Met1-Gln692
Endotoxin
< 1.0 EU/μg of the protein as determined by the LAL method
Purity
> 95 % as determined by SDS-PAGE
Storage
Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
SDS-PAGE
SDS-PAGE

Data Sheet MSDS
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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