Description
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
Bio-activity
Measured by its binding ability in a functional ELISA. When Human PDGF R alpha Antibody is immobilized at 1 μg/mL (100 μL/well), it binds to Biotinylated Recombinant Human PDGF R alpha His-tag Avi-tag with an ED50 of 0.1-1 μg/mL. Measured by its binding ability in a functional ELISA. When Recombinant Human PDGF-AA is used at 2 μg/mL (100 μL/well), it binds to Biotinylated Recombinant Human PDGF R alpha His-tag Avi-tag with a linear range 0.8-100 μg/mL.
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
