Recombinant Human PTPN6 Protein (Lys243-Ile541), C-His-tagged
Product Description
Cat
IMP-6941
Official Symbol
PTPN6
Product Overview
Recombinant protein of human protein tyrosine phosphatase, non-receptor type 6 (PTPN6), transcript variant 1 with C-His tag was expressed in E. coli.
Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
Expression System
E. coli
Species
Human
Tag
C-His
Form
Supplied as a 0.2 μm filtered solution of 25mM TrisHCl, 2mM β-ME, 1mM EDTA, 1mM DTT, 20% Glycerol, pH 7.5
Molecular Mass
35.4 kDa
Protein length
Lys243-Ile541
Endotoxin
< 0.1 EU/μg protein as determined by the LAL method
Purity
> 95% as determined by SDS-PAGE and Coomassie blue staining
Storage
Store at -80 centigrade.
Stability: Stable for at least 3 months from date of receipt under proper storage and handling conditions.
Concentration
lot specific
SDS-PAGE
SDS-PAGE

Data Sheet MSDS
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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