Recombinant Human REN Protein (24-406), His-tagged
Product Description
Cat
IMP-8828
Official Symbol
REN
Product Overview
Human REN (P00797, 24 a.a.-406 a.a.) partial recombinant protein with His tag was expressed in HEK293 cells.
Description
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
Expression System
HEK293
Species
Human
Tag
His
Form
Liquid, In PBS, pH 7.4 ( 10% glycerol)
Molecular Mass
43.1 kDa
Protein length
24-406
AA Sequence
LPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Endotoxin
< 1 EU/μg of protein by the LAL method.
Purity
> 95% by SDS-PAGE
Applications
SDS-PAGE
Storage
Store at 4 centigrade for 1 week. For long term storage store at -20 to -80 centigrade. Aliquot to avoid repeated freezing and thawing.
SDS-PAGE
Quality Control Testing

SDS-PAGE analysis of REN (Human) Recombinant Protein.

Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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