Description
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Bio-activity
Measured by its binding ability in a functional ELISA. When Human ROR1 Antibody is immobilized at 0.5 μg/mL (100 μL/well), Biotinylated Recombinant Human ROR1 Fc Chimera Avi-tag binds with an ED50 of 0.6-3.6 ng/mL. Measured by its binding ability in a functional ELISA. When Recombinant Human/Mouse Wnt-5a Recombinant Human/Mouse Wnt-5a is immobilized at 4 μg/mL (100 μL/well), Biotinylated Recombinant Human ROR1 Fc Chimera Avi-tag binds with an ED50 of 5-40 μg/mL.
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
