Product Overview
Purified recombinant protein of Human R-spondin 2 homolog (Xenopus laevis) (RSPO2), full length, with N-terminal GST and C-terminal His tag, expressed in E. coli.
Description
This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Form
25mM Tris, pH 8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl
