Recombinant Human SIGLEC6 Protein, C-His-tagged
Product Description
Cat
IMP-4938
Official Symbol
SIGLEC6
Product Overview
Recombinant human SIGLEC6 (NP_942142.3) (Gln27-Val331) was expressed with a polyhistidine tag at the C-terminus.
Description
SIGLEC6, also known as CD327, belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family. SIGLEC6 is a sialic acid recognizing protein expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. SIGLEC6 localizes in various compartments such as membrane fraction, extracellular region and so on. SIGLEC6 may show increasing expression human labor and following childbirth, it has been speculated that this expression helps to slow the tempo of human labor. Interestingly, expression of SIGLEC6 is further upregulated in pre-eclampsia, which appears to be a uniquely human disease.
Expression System
HEK293
Species
Human
Tag
C-His
Predicted N Terminal
Ser
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5% mannitol and 0.01% Tween80.
Molecular Mass
The recombinant human SIGLEC6 consists of 317 amino acids and predicts a molecular mass of 35.24 kDa. As a result of glycosylation, it migrates as an approximately 57.07 KDa band in SDS-PAGE under reducing conditions.
Protein length
Gln27-Val331
Endotoxin
< 1.0 EU/μg of the protein as determined by the LAL method
Purity
> 90 % as determined by SDS-PAGE
Storage
Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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