Recombinant Human SLAMF7 Protein (23-226), His-tagged
Product Description
Cat
IMP-6749
Official Symbol
SLAMF7
Product Overview
Recombinant human CD319/SLAMF7 (23-226) protein with His tag was expressed in insect cells.
Description
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed: 11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed: 16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed: 11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed: 23695528).[UniProtKB/Swiss-Prot Function]
Expression System
Insect cells
Species
Human
Tag
His
Form
Presentation State: Purified
State: Liquid purified protein
Buffer System: Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
Molecular Mass
23.4 kDa
Protein length
23-226
AA Sequence
SGPVKELVGSVGGAVTFPLKSKVKQVDSIVWTFNTTPLVTIQPEGGTIIVTQNRNRERVDFPDGGYSLKLSKLKKNDSGIYYVGIYSSSLQQPSTQEYVLHVYEHLSKPKVTMGLQSNKNGTCVTNLTCCMEHGEEDVIYTWKALGQAANESHNGSILPISWRWGESDMTFICVARNPVSRNFSSPILARKLCEGAADDPDSSMLEHHHHHH
Endotoxin
< 1.0 EU/μg protein as determined by the LAL method
Purity
> 95% by SDS-PAGE.
Storage
Store undiluted at 2-8 centigrade for one week or (in aliquots) at -20 to -80 centigrade for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Concentration
lot specific
SDS-PAGE
SDS-PAGE

Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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