Recombinant Human STAT6 Protein (Ser627-Ser837), C-His-tagged
Product Description
Cat
IMP-7277
Official Symbol
Stat6
Product Overview
Purified recombinant protein of Human signal transducer and activator of transcription 6, interleukin-4 induced (STAT6), transcript variant 2 with a C-His tag was expressed in E. coli.
Description
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Expression System
E. coli
Species
Human
Tag
C-His
Form
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
Molecular Mass
23.9 kDa
Protein length
Ser627-Ser837
Endotoxin
< 0.1 ng/μg
Purity
> 95% as determined by SDS-PAGE and Coomassie blue staining
Storage
Store at -80 centigrade.
Stability: Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Concentration
lot specific
Data Sheet MSDS
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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