Recombinant Human TGFBR2 Protein (Thr23-Asp159), C-hFc and Avi-tagged, Biotinylated
Product Description
Cat
IMP-10076
Official Symbol
TGFBR2
Product Overview
Biotinylated recombinant human TGF-beta RII protein (Thr23-Asp159) with a Human IgG1 (Pro100-Lys330) Fc tag and Avi-tag at C-terminus was expressed in Human embryonic kidney cell.
Description
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
Expression System
HEK293
Species
Human
Tag
C-hFc and Avi
Predicted N Terminal
Thr23
Form
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Conjugate
Biotinylated
Molecular Mass
Predicted Molecular Mass: 44 kDa
SDS-PAGE: 56-72 kDa, under reducing conditions.
Protein length
Thr23-Asp159
Bio-activity
When Recombinant Human TGF-beta 1 is immobilized at 0.2 μg/mL (100 μL/well), Biotinylated Recombinant Human TGF-beta RII Fc Chimera Avi-tag binds with an ED50 of 0.2-1.6 ng/mL.
Endotoxin
<0.10 EU/μg of the protein by the LAL method.
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.
Notes
Biotinylated via Avi-tag.
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution
Reconstitute at 250 μg/mL in PBS.
SDS-PAGE
SDS-PAGE

Bioactivity-ELISA 1
Bioactivity

When Recombinant Human TGF-beta 1 is immobilized at 0.2 μg/mL (100 μL/well), Biotinylated Recombinant Human TGF-beta RII Fc Chimera Avi-tag binds with an ED50 of 0.2-1.6 ng/mL.

Data Sheet MSDS
Datasheet MSDS
For research or industrial raw materials, not for personal medical use!

Online Inquiry
Contact Info
Phone
  • 1-631-559-9269
    1-516-512-3133
Fax
  • 1-631-938-8127
Email
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