Recombinant Human TGFBR3 Protein (Gly21-Asp781)

Product Description

Cat

IMP-9729

Official Symbol

TGFBR3

Product Overview

Recombinant human TGF-beta RIII protein (Gly21-Asp781) without tag was expressed in Mouse myeloma cell line.

Description

This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Expression System

Mouse myeloma cell line

Species

Human

Tag

Tag Free

Predicted N Terminal

Gly21

Form

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Molecular Mass

Predicted Molecular Mass: 84 kDa
SDS-PAGE: 100-190 kDa, reducing conditions

Protein length

Gly21-Asp781

Bio-activity

Measured by its ability to inhibit TGF-beta 2 activity on HT-2 mouse T cells. The ED50 for this effect is 20-50 ng/mL in the presence of 0.4 ng/mL of rhTGF-beta 2.

Endotoxin

<0.10 EU/μg of the protein by the LAL method.

Purity

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.

Reconstitution

Reconstitute at 200 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Data Sheet MSDS

Datasheet MSDS

For research or industrial raw materials, not for personal medical use!

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