Recombinant Human TNFRSF18 Protein, C-hFc-tagged, Biotinylated
Product Description
Cat
IMP-1605
Official Symbol
TNFRSF18
Product Overview
Recombinant human TNFRSF18 (Q9Y5U5-1) (Met1-Glu161) was expressed with the Fc region of human IgG1 at the C-terminus. The purified protein was biotinylated in vitro.
Description
GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.
Expression System
HEK293
Species
Human
Tag
C-hFc
Predicted N Terminal
Gln 26
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5% mannitol and 0.01% Tween80.
Molecular Mass
The recombinant human TNFRSF18 consists of 377 amino acids and predicts a molecular mass of 41.5 kDa.
Protein length
Met1-Glu161
Endotoxin
< 1.0 EU/μg protein as determined by the LAL method.
Purity
> 95 % as determined by SDS-PAGE
Storage
Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
SDS-PAGE
SDS-PAGE

Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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