Recombinant Human TNFRSF1B Protein (Pro24-Thr206), Tag Free
Product Description
Cat
IMP-7821
Official Symbol
TNFRSF1B
Product Overview
Purified recombinant protein of Human tumor necrosis factor receptor superfamily, member 1B (sTNF-RII / TNFRSF1B) without tag was expressed in E. coli.
Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Expression System
E. coli
Species
Human
Tag
Tag free
Form
1×PBS
Molecular Mass
20 kDa
Protein length
Pro24-Thr206
Endotoxin
< 0.01 ng/μg protein as determined by the LAL method
Purity
> 95% as determined by Coomassie stained SDS-PAGE.
Storage
Store at -80 centigrade.
Stability: Unopened vial can be stored between 2 and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Concentration
lot specific
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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