Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Storage
Store at -80 centigrade on dry atmosphere, lyophilized antibodies are stable at least 2 years. After reconstitution with deionized water, store at -20 centigrade or lower. Aliquot to avoid repeated freezing and thawing.
