Recombinant Human TNFSF8 Protein (Gln63-Asp234), N-mFc and C-6×His-tagged
Product Description
Cat
IMP-7851
Official Symbol
TNFSF8
Product Overview
Recombinant Human CD30 Ligand Protein with N-Mouse Fc (Pro99-Lys330) and C-6×His tag was expressed in HEK293.
Description
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
Expression System
HEK293
Species
Human
Tag
N-mFc and C-6×His
Form
Lyophilized from sterile PBS, pH 7.4. Normally 5-8 % trehalose is added as protectants before lyophilization.
Molecular Mass
48.0 kDa
Protein length
Gln63-Asp234
Purity
> 95%
Applications
ELISA
Storage
Store the lyophilized protein at -20 centigrade. After reconstitution, store the protein at -80 centigrade for 12 months. Avoid repeated freezing and thawing.
Stability: 12 months from date of despatch.
Reconstitution
Reconstitute with deionized water.
Bioactivity-ELISA 1
Bioactivity

Data Sheet MSDS
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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