Recombinant Human TNFSF9 Protein (Pro52-Glu254), N-mFc and C-6×His-tagged
Product Description
Cat
IMP-7858
Official Symbol
TNFSF9
Product Overview
Recombinant Human 4-1BB Ligand Protein with N-Mouse Fc (Pro99-Lys330) and C-6×His tag was expressed in HEK293.
Description
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Expression System
HEK293
Species
Human
Tag
N-mFc and C-6×His
Form
Lyophilized from sterile PBS, pH 7.4. Normally 5-8 % trehalose is added as protectants before lyophilization.
Molecular Mass
49.8 kDa
Protein length
Pro52-Glu254
Purity
> 95%
Storage
Store the lyophilized protein at -20 centigrade. After reconstitution, store the protein at -80 centigrade for 12 months. Avoid repeated freezing and thawing.
Stability: 12 months from date of despatch.
Reconstitution
Reconstitute with deionized water.
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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