Description
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.
Bio-activity
Measured by its binding ability in a functional ELISA. When Recombinant Human IL-23 Protein is immobilized at 1 μg/mL (100 μL/well), the concentration of Recombinant Cynomolgus Monkey IL-23R Fc Chimera that produces 50% of the optimal binding response is found to be approximately 50-250 ng/mL.
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
