Recombinant Monkey LAIR1 Protein (Gln22-His163), C-hFc-tagged
Product Description
Cat
IMP-9572
Official Symbol
LAIR1
Product Overview
Recombinant Cynomolgus LAIR1 protein (Gln22-His163) with a Human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in Human embryonic kidney cell.
Description
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants.
Expression System
HEK293
Species
Monkey
Tag
C-hFc
Predicted N Terminal
Gln22, deduced from deblocked sequence at Glu23
Form
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Molecular Mass
Predicted Molecular Mass: 42 kDa
SDS-PAGE: 58-64 kDa, under reducing conditions
Protein length
Gln22-His163
Bio-activity
Measured by its binding ability in a functional ELISA. When Bovine Collagen I is coated at 10 μg/mL, 100 μL/well, Recombinant Cynomolgus Monkey LAIR1 Fc Chimera binds with an ED50 of 1-6 ng/mL.
Endotoxin
<0.10 EU/μg of the protein by the LAL method.
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.
Notes
Disulfide-linked homodimer
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution
Reconstitute at 500 μg/mL in PBS.
SDS-PAGE
SDS-PAGE

Bioactivity-ELISA 1
Binding Activity

Measured by its binding ability in a functional ELISA. When Bovine Collagen I is coated at 10 μg/mL, 100 μL/well, Recombinant Cynomolgus Monkey LAIR1 Fc Chimera binds with an ED50 of 1-6 ng/mL.

Data Sheet MSDS
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Online Inquiry
Contact Info