Recombinant Mouse Ace2 Protein (Gln18-Ser740), C-10×His-tagged
Product Description
Cat
IMP-10639
Official Symbol
Ace2
Product Overview
Recombinant Mouse ACE-2 protein (Gln18-Thr740) with a C-terminal 10-His tag was expressed in Chinese Hamster Ovary cell line.
Description
Predicted to enable identical protein binding activity; peptidase activity; and virus receptor activity. Involved in positive regulation of cardiac muscle contraction and tryptophan transport. Located in brush border membrane and cytoplasm. Is expressed in several structures, including brain; cardiovascular system; extraembryonic component; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2).
Expression System
CHO
Species
Mouse
Tag
C-10×His
Predicted N Terminal
No results obtained: Gln18 predicted
Form
Supplied as a 0.2 μm filtered solution in Tris, NaCl and ZnCl2.
Molecular Mass
Predicted Molecular Mass: 85 kDa
SDS-PAGE: 110 kDa, reducing conditions
Protein length
Gln18-Ser740
Bio-activity
Measured by its ability to cleave a fluorogenic peptide substrate, Mca-YVADAPK(Dnp)-OH. The specific activity is >400 pmol/min/μg, as measured under the described conditions.
Endotoxin
<1.0 EU/μg of the protein by the LAL method.
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.
Notes
Recombinant Mouse ACE-2 is prone to proteolytic cleavage at C-terminus. The predominant form of the purified protein lacks the His tag.
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
6 months from date of receipt, -20 to -70 centigrade as supplied.
3 months, -20 to -70 centigrade under sterile conditions after opening.
Bioactivity-ELISA 1
Enzyme Activity

Measured by its ability to cleave a fluorogenic peptide substrate, Mca-YVADAPK(Dnp)-OH. The specific activity is >400 pmol/min/μg, as measured under the described conditions.

Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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