Recombinant Mouse ACVR1B Protein (Leu32-Glu126), C-Fc-tagged

Product Description

Cat

IMP-10188

Official Symbol

ACVR1B

Product Overview

Recombinant Mouse Activin RIB/ALK-4 protein (Leu32-Glu126) with a human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in Mouse myeloma cell line.

Description

This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.

Expression System

Mouse myeloma cell line

Species

Mouse

Tag

C-Fc

Predicted N Terminal

Leu32

Form

Lyophilized from a 0.2 μm filtered solution in PBS.

Molecular Mass

Predicted Molecular Mass: 37.2 kDa (monomer)
SDS-PAGE: 44 kDa, reducing conditions

Protein length

Leu32-Glu126

Bio-activity

Measured by its binding ability in a functional ELISA. Immobilized rmActivin RIB/Fc Chimera at 1 μg/mL (100 μL/well) can bind rmCripto with a linear range of 0.8-100 ng/mL.

Endotoxin

<0.10 EU/μg of the protein by the LAL method.

Purity

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Notes

Disulfide-linked homodimer

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.

Reconstitution

Reconstitute at 100 μg/mL in sterile PBS.

Data Sheet MSDS

Datasheet MSDS

For research or industrial raw materials, not for personal medical use!

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