Recombinant Mouse Cd40 protein, C-His-Avi Tag, Biotinylated
Product Description
Cat
IMP-380
Official Symbol
Cd40
Product Overview
Biotinylated Recombinant Mouse Cd40 protein(NP_035741.2) (Met1-Arg193) was expressed in HEK293, fused with a C-terminal AVI tagged polyhistidine tag at the C-terminus (his-AVI).
Description
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.
Expression System
HEK293
Species
Mouse
Tag
C-His-Avi Tag
Predicted N Terminal
Leu 20
Form
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass
The recombinant mouse CD40 consists of 199 amino acids and predicts a molecular mass of 22.5 kDa.
Protein length
Met1-Arg193
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
Purity
> 95 % as determined by SDS-PAGE.
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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