Product Overview
Recombinant mouse CD48 (NP_031675.1) without the propeptide, corresponding to the amino acids (Met1-Arg216) was expressed with a C-terminal polyhistidine tag. The purified protein was biotinylated in vitro.
Description
Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules. CD2 and 2B4 (CD244) are known ligands for CD48. CD48 protein is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. CD48 protein performs biological functions in a variety processes including adhesion, pathogen recognition, cellular activation, and cytokine regulation, and emerges as a critical effector molecule in immune responses.
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5% mannitol and 0.01% Tween80.
Molecular Mass
The secreted recombinant mouse CD48 consists of 205 amino acids and has a calculated molecular mass of 23.7 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 45.5 kDa in SDS-PAGE under reducing conditions.
