Description
The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene.
Bio-activity
Measured by the ability of the immobilized protein to support the adhesion of human monocyte-derived dendritic cells. When 5 × 10^4 cells/well are added to mouse CD83/Fc Chimera coated plates (2.5 μg/mL with 100 μL/well), approximately 50-75% will adhere after 1 hour incubation at room temperature. Optimal dilutions should be determined by each laboratory for each application.
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
