Recombinant Mouse Cx3cl1 Protein (Leu22-Lys105), Tag Free
Product Description
Cat
IMP-7029
Official Symbol
CX3CL1
Product Overview
Purified recombinant protein of Mouse chemokine (C-X3-C motif) ligand 1 (Cx3cl1 / Fractalkine) without tag was expressed in E. coli.
Description
Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 and to integrins ITGAV: ITGB3 and ITGA4: ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (By similarity). The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed: 9177350, PubMed: 10382755).[UniProtKB/Swiss-Prot Function]
Expression System
E. coli
Species
Mouse
Tag
Tag free
Form
10mM NaH2PO4, 0.15 M NaCl, pH7.2
Molecular Mass
9.59 kDa
Protein length
Leu22-Lys105
Purity
> 98% as determined by Coomassie stained SDS-PAGE.
Storage
Store at -80 centigrade.
Stability: Unopened vial can be stored between 2 and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Concentration
lot specific
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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