Description
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45.
Bio-activity
Measured by its binding ability in a functional ELISA. When Recombinant Mouse IFN-alpha/beta R2 Fc Chimera is immobilized at 2 μg/mL, it binds to Recombinant Mouse IFN-alpha/beta R1 in the presence of Recombinant Mouse Limitin/IFN-zeta. The concentration of rmIFN-alpha/beta R1 that produces 50% of the optimal binding response was found to be approximately 1-4 μg/mL.
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
