Recombinant Mouse TNFRSF13B Protein (Phe5-Thr129), C-hFc-tagged

Product Description

Cat

IMP-9589

Official Symbol

Tnfrsf13b

Product Overview

Recombinant Mouse TACI/TNFRSF13B protein (Phe5-Thr129) with a Human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in Mouse myeloma cell line.

Description

The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17.

Expression System

Mouse myeloma cell line

Species

Mouse

Tag

C-hFc

Predicted N Terminal

Phe5

Form

Lyophilized from a 0.2 μm filtered solution in PBS.

Molecular Mass

Predicted Molecular Mass: 41 kDa (monomer)
SDS-PAGE: 47 kDa, reducing conditions

Protein length

Phe5-Thr129

Bio-activity

Measured by its ability to inhibit BAFF-mediated proliferation of anti-IgM stimulated mouse B cells. The ED50 for this effect is 3-10 ng/mL in the presence of 2.5 ng/mL of rhBAFF.

Endotoxin

<0.10 EU/μg of the protein by the LAL method.

Purity

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Notes

Disulfide-linked homodimer

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.

Reconstitution

Reconstitute at 100 μg/mL in sterile PBS.

Data Sheet MSDS

Datasheet MSDS

For research or industrial raw materials, not for personal medical use!

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