Product Overview
Purified recombinant protein of Mouse tumor necrosis factor (ligand) superfamily, member 18 (Tnfsf18), with C-terminal Myc/DDK tag, expressed in HEK293T cells.
Description
Cytokine that binds to TNFRSF18/AITR/GITR (PubMed: 14521928, PubMed: 14647196). Regulates T-cell responses (PubMed: 14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed: 14608036, PubMed: 15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed: 14521928, PubMed: 14647196, PubMed: 18178614). Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity). Promotes leukocyte adhesion to endothelial cells (PubMed: 23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed: 24107315).[UniProtKB/Swiss-Prot Function]
Form
25mM Tris.HCl, pH 7.3, 100mM glycine, 10% glycerol
