Recombinant Mouse Tnfsf18 Protein, C-Myc/DDK-tagged

Product Description

Cat

IMP-7845

Official Symbol

TNFSF18

Product Overview

Purified recombinant protein of Mouse tumor necrosis factor (ligand) superfamily, member 18 (Tnfsf18), with C-terminal Myc/DDK tag, expressed in HEK293T cells.

Description

Cytokine that binds to TNFRSF18/AITR/GITR (PubMed: 14521928, PubMed: 14647196). Regulates T-cell responses (PubMed: 14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed: 14608036, PubMed: 15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed: 14521928, PubMed: 14647196, PubMed: 18178614). Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity). Promotes leukocyte adhesion to endothelial cells (PubMed: 23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed: 24107315).[UniProtKB/Swiss-Prot Function]

Expression System

HEK293T

Species

Mouse

Tag

C-Myc/DDK

Form

25mM Tris.HCl, pH 7.3, 100mM glycine, 10% glycerol

Molecular Mass

19.7 kDa

AA Sequence

MEEMPLRESSPQRAERCKKSWLLCIVALLLMLLCSLGTLIYTSLKPTAIESCMVKFELSSSKWHMTSPKPHCVNTTSDGKLKILQSGTYLIYGQVIPVDKKYIKDNAPFVVQIYKKNDVLQTLMNDFQILPIGGVYELHAGDNIYLKFNSKDHIQKNNTYWGIILMPDLPFISTRTRPLEQKLISEEDLAANDILDYKDDDDKV

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining.

Storage

Store at -80 centigrade after receiving vials.
Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Concentration

> 50 μg/mL as determined by microplate BCA method.

Data Sheet MSDS

Datasheet MSDS

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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