Product Overview
Recombinant rabbit IL12B (XP_002710393.1)(Met1-Asn324) was expressed with a polyhistidine tag at the C-terminus, constructed the plasmid 1; Recombinant rabbit IL23A (XP_002711125.1)(Met1-Pro191) constructed the plasmid 2. The two plasmids were co-expressed and the rabbit IL12B&IL23A heterodimer was purified.
Description
Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5% mannitol and 0.01% Tween80.
