Recombinant Rabbit IL2 Protein (Ala21-Ser153)
Product Description
Cat
IMP-10623
Official Symbol
IL2
Product Overview
Recombinant Rabbit IL-2 protein (Ala21-Ser153) with an N-terminal Met was expressed in E. coli.
Description
This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
Expression System
E. coli
Species
Rabbit
Tag
Tag Free
Predicted N Terminal
Met&Ala21
Form
Lyophilized from a 0.2 μm filtered solution in Sodium Acetate with BSA as a carrier protein.
Molecular Mass
Predicted Molecular Mass: 15.2 kDa
SDS-PAGE: 14 kDa, reducing conditions
Protein length
Ala21-Ser153
Bio-activity
Measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells. The ED50 for this effect is 0.015-0.075 ng/mL.
Endotoxin
<0.01 EU/μg of the protein by the LAL method.
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.
Notes
Monomer
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution
Reconstitute at 100 μg/mL in 100 mM acetic acid containing at least 0.1% human or bovine serum albumin.
Data Sheet MSDS
Datasheet MSDS
For research or industrial raw materials, not for personal medical use!

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