Recombinant Rat Cd52 Protein, C-hFc-tagged

Product Description

Cat

IMP-4258

Official Symbol

Cd52

Product Overview

Recombinant rat ILCD52 (Q63064) (Met1-Ala69) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Description

CD52 / CDW52 is a small glycosylphosphatidylinositol (GPI) anchored glycoprotein. It has a mature peptide comprising only 12 amino acids and is abundantly expressed on human lymphocytes. From the clinical point of view this protein is an important target for therapeutic interventions aimed at leukocyte depletion in hematological malignancies and post-transplant immunosuppression. CD52 / CDW52 may play a role in carrying and orienting carbohydrate. It is an unusually good target for complement-mediated cell lysis.

Expression System

HEK293

Species

Rat

Tag

C-hFc

Predicted N Terminal

Gly 24

Form

Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5% mannitol and 0.01% Tween80.

Molecular Mass

The recombinant rat CD52/Fc is a disulfide-linked homodimer. The reduced monomer comprises 287 amino acids and has a predicted molecular mass of 31.4 kDa. The apparent molecular mass of the protein is approximately 53 kDa in SDS-PAGE under reducing conditions.

Protein length

Met1-Ala69

Endotoxin

< 1.0 EU/μg of the protein as determined by the LAL method

Purity

> 70 % as determined by SDS-PAGE

Storage

Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Reconstitution

A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SDS-PAGE

Data Sheet MSDS

Datasheet MSDS

For research or industrial raw materials, not for personal medical use!

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