Recombinant Rat IL7R Protein (Glu21-Asp239), C-mFc-tagged
Product Description
Cat
IMP-10440
Official Symbol
Il7r
Product Overview
Recombinant Rat IL-7 R alpha protein (Glu21-Asp239) with a Mouse IgG2a (Glu98-Lys330) Fc tag at C-terminus was expressed in Mouse myeloma cell line.
Description
The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found.
Expression System
Mouse myeloma cell line
Species
Rat
Tag
C-mFc
Predicted N Terminal
Glu21
Form
Lyophilized from a 0.2 μm filtered solution in PBS.
Molecular Mass
Predicted Molecular Mass: 52.2 kDa (monomer)
SDS-PAGE: 60-75 kDa under reducing conditions
Protein length
Glu21-Asp239
Bio-activity
Measured by its binding ability in a functional ELISA. When 25 ng/mL of rrIL-7R alpha/Fc Chimera is captured by goat anti-mouse IgG Fc Chimera coated plate, the concentration of rmIL-7 that produces 50% optimal binding response is found to be approximately 10-30 ng/mL.
Endotoxin
<1.0 EU/μg of the protein by the LAL method.
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Notes
Disulfide-linked homodimer
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution
Reconstitute at 100 μg/mL in PBS.
Data Sheet MSDS
Datasheet MSDS
For research or industrial raw materials, not for personal medical use!

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