Recombinant Rhesus IL6 Protein, No Tag
Product Description
Cat
IMP-4749
Official Symbol
IL6
Product Overview
Recombinant the rhesus IL6 (NP_001036198.2) (Pro29-Met212) was expressed and purified.
Description
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity.
Expression System
E. coli
Species
Rhesus
Tag
No Tag
Predicted N Terminal
Met
Form
Lyophilized from sterile 50% acetonitrile, 0.1% TFA, 5 % trehalose, 5% mannitol and 0.01% Tween80.
Molecular Mass
The recombinant rhesus IL6 consists of 185 amino acids and has a calculated molecular mass of 21 kDa.
Protein length
Pro29-Met212
Endotoxin
Please contact us for more information.
Purity
> 85 % as determined by SDS-PAGE
Storage
Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
SDS-PAGE
SDS-PAGE

Bioactivity-Cell based assay 1
Bioactivity-Cell based assay

Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 5-30 ng/mL.

Data Sheet MSDS
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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