Recombinant SARS-CoV-2 PLpro Protein, No Tag
Product Description
Cat
IMP-4899
Official Symbol
PLpro
Product Overview
Recombinant SARS-CoV-2 (2019-nCoV) papain-like protease (QVD65746.1) (Glu1564-Val1880) was expressed with a polyhistidine tag at the N-terminus.
Description
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.
Expression System
E. coli
Species
SARS-CoV-2
Tag
No Tag
Predicted N Terminal
Met
Form
Lyophilized from sterile 20mM Tris 500mM NaCl, pH 7.4, 5 % trehalose, 5% mannitol and 0.01% Tween80.
Molecular Mass
The recombinant SARS-CoV-2 (2019-nCoV) Plpro / papain-like protease (His Tag) consists of 324 amino acids and predicts a molecular mass of 36.79 kDa.
Protein length
Glu1564-Val1880
Endotoxin
Please contact us for more information.
Purity
> 90 % as determined by SDS-PAGE
Storage
Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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