The vast majority of the targets of approved drugs are proteins. Knowledge of which proteins are the targets of approved drugs enables the division of the human proteome into two classes: approved drug targets and non-targets.

Suitable drug targets should have a critical role in the disease process with less significant involvement in other important processes to limit potential side-effects, have an expression pattern allowing for drug efficacy by for example showing tissue-specific expression, and have structural and functional properties allowing for drug specificity.

A potential protein drug target must be linked to a disease process. Target proteins control the action and the kinetic behavior of drugs within the organism. A druggable protein is one that possesses folds that favor interactions with small drug-like molecules, be they endogenous or extraneous, and therefore is one that contains a binding site. The elucidation of structure, conformational signaling, and catalytic properties of particular target proteins facilitates a rational design of drugs and biotechnological processes.

At present, international competition in drug research is mainly focused on the research of drug targets. Drug target research has an extremely important role in promoting drug discovery and development.

Creative BioMart provides high-quality GMP drug target proteins, especially related to immune-checkpoint, to accelerate your drug discovery and development. Please feel free to contact us for more product information.