A pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has greatly threatened public health worldwide in the past year. Still, there is an immediate need for the identification of effective drugs to contain the disastrous virus outbreak. Global efforts have been underway at a war footing to identify the best drug combination to address the disease.

The SARS-CoV-2 infection process starts with the viral entry mediated by the interaction of the spike (S) glycoprotein with the host angiotensin-converting enzyme 2 (ACE2) receptor, and cleavage of the S protein by the host transmembrane serine protease 2 (TMPRSS2) before the fusion to the host cell membrane.

Academic labs and drug discovery organizations worldwide are working tirelessly to evaluate compounds that can inhibit the spread of SARS-CoV-2 in humans. It is essential to first identify drug targets and subsequently identify and evaluate compounds and biologics that can effectively engage these targets to inhibit the spread of the virus.

Creative BioMart Immune Checkpoints provides proteins that focus on the main virus-based and host-based targets to guide efforts in medicinal chemistry and to discover new drugs for this devastating disease. Some of the featured COVID-19 target proteins are listed below that can be used to accelerate your drug discovery and development. Please feel free to contact us for more product information.

Cat#No#	Product Name	Expression System	Species	Protein length	Tag	Inquiry
IMP-1002	Recombinant Human ACE2 protein, C-His tag	HEK293	Human	Gln18-Ser740	C-His tag
IMP-798	Recombinant Human AXL protein, C-His tag	HEK293	Human	Ala26-Pro440	C-His tag
IMP-801	Recombinant Mouse AXL protein, C-His tag	HEK293	Mouse	Ala19-Pro443	C-His tag
IMP-846	Recombinant Human ACE2 protein, C-hFc tag	HEK293	Human	Gln18-Ser740	C-hFc tag
IMP-847	Recombinant COVID-19 3CLpro protein, N-His tag	E.coli	COVID-19	Ser1-Gln306	N-His tag
IMP-849	Recombinant Human ACE2 protein, C-mFc tag	HEK293	Human	Gln18-Ser740	C-mFc tag
IMP-853	Recombinant COVID-19 PLpro protein, No tag	E.coli	COVID-19	Glu1564-Lys1878	No tag
IMP-854	Recombinant COVID-19 NSP1 protein, C-His tag	E.coli	COVID-19	Met1-Gly180	C-His tag
IMP-855	Recombinant COVID-19 NSP7 protein, C-His tag	E.coli	COVID-19	Ser1-Gln83	C-His tag
IMP-856	Recombinant COVID-19 NSP8 protein, C-His tag	E.coli	COVID-19	Ala1-Gln198	C-His tag
IMP-857	Recombinant COVID-19 NSP10 protein, N-His tag	E.coli	COVID-19	Ala1-Gln139	N-His tag
IMP-858	Recombinant COVID-19 NSP2 protein, C-His tag	E.coli	COVID-19	Ala1-Gly638	C-His tag
IMP-859	Recombinant COVID-19 NSP14 protein, N-His tag	E.coli	COVID-19	Ala1-Gln527	N-His tag
IMP-860	Recombinant COVID-19 NSP13 protein, C-His tag	E.coli	COVID-19	Ala5325-Gln5925	C-His tag
IMP-875	Recombinant Mouse ACE2 protein, C-His tag	HEK293	Mouse	Gln18-Thr740	C-His tag
IMP-880	Recombinant Mouse AXL protein, C-hFc tag	HEK293	Mouse	Ala19-Pro443	C-hFc tag
IMP-889	Recombinant Rhesus Macaque ACE2 protein, C-His tag	HEK293	Rhesus Macaque	Gln18-Val739	C-His tag
IMP-890	Recombinant Rhesus Macaque ACE2 protein, C-hFc tag	HEK293	Rhesus Macaque	Gln18-Val739	C-hFc tag
IMP-975	Recombinant Human ACE2 Protein, C-Avi-His tag, Biotinylated	HEK293	Human	Gln18-Ser740	C-Avi-His tag